Published papers
- Schepps MA, Seurat J, Mentré F, Wong WK.
Design optimization of longitudinal studies using metaheuristics: Application to lithium pharmacokinetics.
Stat Methods Med Res., 2025;34(8):1633-1645.
Link to full text - Fayette L, Brendel K, Mentré F.
Using Fisher Information Matrix to predict uncertainty in covariate effects and power to detect their relevance in Non-Linear Mixed Effect Models in pharmacometrics.
J Pharmacokinet Pharmacodyn, 2025;52(4):38.
Link to full text - Duflot T, Fayette L, Konecki C, Seurat J, Feliu C, Scala-Bertola J, Djerada Z.
Assessing the Impact of Multiple Imputation Algorithms on Pharmacokinetic Model Performance: A Simulation-Based Study.
AAPS J, 2025;27(4):77.
Link to abstract - Fayette L, Leroux R, Mentré F, Seurat J.
Robust and Adaptive Two-stage Designs in Nonlinear Mixed Effect Models.
AAPS J, 2023;25(4):71.
Link to full text - Seurat J, Tang Y, Mentré F, Nguyen TT.
Finding optimal design in nonlinear mixed effect models using multiplicative algorithms.
Computer Methods and Programs in Biomedicine, 2021;207: 106-126.
Link to full text - Seurat J, Nguyen TT, Mentré F.
Robust designs accounting for model uncertainty in longitudinal studies with binary outcomes.
Statistical Methods in Medical Research, 2020;29(3):934-952.
Link to full text - Seurat J, Girard P, Goteti K, Mentré F.
Comparison of various phase I combination therapy designs in oncology for evaluation of early tumor shrinkage using simulations.
CPT Pharmacometrics and Systems Pharmacology, 2020, 9(12):686-694.
Link to full text - Loingeville F, Nguyen TT, Riviere MK, Mentré F.
Robust designs in longitudinal studies accounting for parameter and model uncertainties - application to count data.
Journal of Biopharmaceutical Statistics, 2020, 30(1):31-45.
Link to full text - Dumont C, Lestini G, Le Nagard H, Mentré F, Comets E, Nguyen TT.
PFIM 4.0, an extended R program for design evaluation and optimization in nonlinear mixed-effect models.
Computer Methods and Programs in Biomedicine, 2018, 156: 217-229.
Link to full text - Nguyen THT, Nguyen TT, Mentré F.
Individual Bayesian information matrix for predicting estimation error and shrinkage of individual parameters accounting for data below the limit of quantification: Bayesian information matrix accounting for data below LOQ.
Pharmaceutical Research, 2017, 34(10):2119-2130.
Link to full text - Riviere MK, Ueckert S, Mentré F.
An MCMC method for the evaluation of the Fisher information matrix for non-linear mixed effect models.
Biostatistics, 2016, 17(4): 737-50.
Link to full text - Lestini G, Mentré F, Magni P.
Optimal design for informative protocols in xenograft tumor growth inhibition experiments in mice.
AAPS Journal, 2016, 18(5):1233-1243.
Link to full text - Lestini G, Dumont C, Mentré F.
Influence of the size of cohorts in adaptive design for nonlinear mixed effects models: an evaluation by simulation for a pharmacokinetic and pharmacodynamic model for a biomarker in oncology.
Pharmaceutical Research, 2015, 32(10):3159-3169.
Link to full text - Petit C, Jullien V, Samson A, Guedj J, Kiechel JR, Zohar S, Comets E.
Designing a pediatric study for an Antimalarial Drug by Using Information from Adults.
Antimicrobial Agents and Chemotherapy, 2015, 60(3):1481-91.
Link to full text - Nyberg J, Bazzoli C, Ogungbenro K, Aliev A, Leonov S, Duffull S, Hooker AC, Mentré F.
Methods and software tools for design evaluation for population pharmacokinetics-pharmacodynamics studies.
British Journal of Clinical Pharmacology, 2015, 79(1):6-17.
Link to full text - Dumont C, Chenel M, Mentré F.
Influence of covariance between random effects in design for nonlinear mixed effect models with an illustration in paediatric pharmacokinetics.
Journal of Biopharmaceutical Statistics, 2014, 24:3, 471-492.
Link to full text - Nguyen TT, Mentré F.
Evaluation of the Fisher information matrix in nonlinear mixed effect models using adaptive Gaussian quadrature.
Computational Statistics & Data Analysis, 2014, 80:57–69.
Link to full text - Combes FP, Retout S, Frey N, Mentré F.
Power of the likelihood ratio test and of the correlation test using empirical Bayes estimates for various shrinkages in population pharmacokinetics.
CPT: Pharmacometrics & Systems Pharmacology, 2014, 3: e109.
Link to full text - Mentré F, Chenel M, Comets E, Grevel J, Hooker A, Karlsson MO, Lavielle M, Gueorguieva I.
Current use and developments needed for optimal design in pharmacometrics: a study performed amongst DDMoRe's European Federation of Pharmaceutical Industries and Associations (EFPIA) members.
CPT: Pharmacometrics & Systems Pharmacology, 2013, 2:e46.
Link to full text - Dumont C, Mentré F, Gaynor C, Brendel K, Gesson C, Chenel M.
Optimal sampling times for a drug and its metabolite using SIMCYP© simulations as prior information.
Clinical Pharmacokinetics, 2013, 52:43-57.
Link to full text - Combes FP, Retout S, Frey N, Mentré F.
Prediction of shrinkage of individual parameters using the Bayesian information matrix in non-linear mixed effect models with evaluation in pharmacokinetics.
Pharmaceutical Research, 2013, 30:2355-2367.
Link to full text - Nguyen TT, Bazzoli C, Mentré F.
Design evaluation and optimisation in crossover pharmacokinetic studies analysed by nonlinear mixed effects models.
Statistics in Medicine, 2012, 31: 1043-1058.
Link to full text - Guedj J, Bazzoli C, Neuman A.U, Mentré F.
Design evaluation and optimization for models of hepatitis C viral dynamics.
Statistics in Medicine, 2011, 30:1045-1056.
Link to abstract - Bazzoli C, Retout S, Mentré F.
Design evaluation and optimisation in multiple response nonlinear mixed effect models: PFIM 3.0.
Computer Methods and Programs in Biomedicine, 2010, 98: 55-65.
Link to full text - Retout, S., Comets, E., Bazzoli, C. et Mentré, F. Design
Optimisation in nonlinear mixed effects models using cost functions:application to a joint model of infliximab and methotrexate pharmacokinetics.
Communication in Statistics: Theory and Methods, 2009, 38 : 3351–3368.
Link to full text - Bazzoli C, Retout S, Mentré F.
Fisher information matrix for nonlinear mixed effects multiple response models: evaluation of the appropriateness of the first order linearization using a pharmacokinetic/pharmacodynamic model.
Statistics in Medicine, 2009, 28 : 1940-1956.
Link to full text - Retout S, Comets E, Samson A, Mentré F.
Design in nonlinear mixed effects models: optimization using the Fedorov-Wynn algorithm and power of theWald test for binary covariates.
Statistics in Medicine, 2007, 26 : 5162-79.
Link to abstract - Retout S, Mentré F.
Further developments of the Fisher information matrix in nonlinear mixed-effects models with evaluation in population pharmacokinetics.
Journal of Biopharmaceutical Statistics, 2003, 13: 209-227.
Link to abstract - Retout S, Mentré F.
Optimisation of individual and population designs using Splus.
Journal of Pharmacokinetic and Pharmacodynamics, 2003, 30: 417-443.
Link to abstract - Duffull S, Retout S, Mentré F.
The use of simulated annealing for finding optimal population designs.
Computer Methods and Programs in Biomedicine, 2002, 69: 25-35.
Link to abstract - Retout S, Mentré F, Bruno R.
Fisher information matrix for nonlinear mixed-effects models: evaluation and application for optimal design of enoxaparin population pharmacokinetics.
Statistics in Medicine, 2002, 21: 2623-2639.
Link to abstract - Retout S, Duffull S, Mentré F.
Development and implementation of the population Fisher information matrix for evaluation of population pharmacokinetic designs.
Computer Methods and Programs in Biomedicine, 2001, 65: 141-151.
Link to abstract - Mentré F, Dubruc C, Thénot JP.
Population pharmacokinetic analysis of mizolastine solution in children with optimisation of the experimental design.
Journal of Pharmacokinetics and Pharmacodynamics, 2001, 28: 299-319.
Link to abstract - Duffull S, Mentré F, Aarons L.
Optimal design of population pharmacodynamic experiment for ivabradine.
Pharmaceutical Research, 2001, 18: 83-89.
Link to abstract - Merlé Y, Mentré F.
Optimal sampling times for Bayesian estimation of the pharmacokinetic parameters of nortriptyline during therapeutic drug monitoring.
Journal of Pharmacokinetics and Biopharmaceutics, 1999, 27: 85-101.
Link to abstract - Tod M, Mentré F, Merlé Y, Mallet A.
Robust optimal design for the estimation of hyperparameters in population pharmacokinetics.
Journal of Pharmacokinetics and Biopharmaceutics, 1998, 26: 689-716.
Link to abstract - Mentré F, Mallet A, Baccar D.
Optimal design in random-effects regression models.
Biometrika, 1997, 84: 429-442.
Link to abstract - Merlé Y, Mentré F.
Stochastic optimization algorithms of a Bayesian design criterion for Bayesian parameter estimation in nonlinear regression models. Application in pharmacokinetics.
Mathematical Biosciences, 1997, 144: 45-70.
Link to abstract - Mentré F, Burtin P, Merlé Y, van Bree J, Mallet A, Steimer JL.
Sparse-sampling optimal design in pharmacokinetics and toxicokinetics.
Drug Information Journal, 1995, 19: 997-1019. - Merlé Y, Mentré F.
Bayesian design criteria: computation, comparison and application to a pharmacokinetic and pharmacodynamic model.
Journal of Pharmacokinetics and Biopharmaceutics, 1995, 23: 101-124.
Link to abstract - Merlé Y, Mentré F, Mallet A, Aurengo A.
Designing an optimal experiment for Bayesian estimation: application to the kinetic of iodine thyroid uptake.
Statistics in Medicine, 1994, 13: 185-196.
Link to abstract
