Published papers
Bazzoli C, Retout S, Mentré F. Design evaluation and optimisation in multiple response nonlinear mixed effect models: PFIM 3.0, Computer Methods and Programs in Biomedicine, 2009, [Epub ahead of print]. Link to full text
Retout, S., Comets, E., Bazzoli, C. et Mentré, F. Design optimisation in nonlinear mixed effects models using cost functions:application to a joint model of infliximab and methotrexate pharmacokinetics, Communication in Statistics: Theory and Methods, 2009, 38 : 3351–3368. Link to full text
Bazzoli C, Retout S, Mentré F. Fisher information matrix for nonlinear mixed effects multiple response models: evaluation of the appropriateness of the first order linearization using a pharmacokinetic/pharmacodynamic model, Statistics in Medicine, 2009, 28 : 1940-1956. Link to full text
Retout S, Comets E, Samson A, Mentré F. Design in
nonlinear mixed effects models: optimization using the Fedorov-Wynn
algorithm and power of theWald test for binary
covariates, Statistics in Medicine, 2007, 26 : 5162-79. Link to
abstract
Retout S, Mentré F.
Further developments of the Fisher information matrix in nonlinear
mixed-effects models with evaluation in population pharmacokinetics, Journal of Biopharmaceutical Statistics, 2003, 13: 209-227. Link to abstract
Retout S, Mentré F. Optimisation of individual and population designs using Splus, Journal
of Pharmacokinetic and Pharmacodynamics, 2003, 30: 417-443. Link
to abstract
Duffull S, Retout S,
Mentré F. The use of simulated annealing for finding optimal
population designs, Computer Methods and Programs in Biomedicine, 2002, 69: 25-35. Link
to abstract
Retout S, Mentré F, Bruno
R. Fisher information matrix for
nonlinear mixed-effects models: evaluation and application for optimal
design of enoxaparin population pharmacokinetics, Statistics in Medicine, 2002, 21: 2623-2639. Link
to abstract
Retout S, Duffull S, Mentré F. Development and implementation of
the population Fisher information matrix for evaluation of population
pharmacokinetic designs, Computer Methods and Programs in Biomedicine, 2001, 65: 141-151. Link to abstract
Mentré F, Dubruc C,
Thénot JP. Population pharmacokinetic analysis of mizolastine
solution in children with optimisation of the experimental design, Journal of Pharmacokinetics and Pharmacodynamics, 2001, 28: 299-319. Link to abstract
Duffull S, Mentré F,
Aarons L. Optimal design of population pharmacodynamic experiment for
ivabradine, Pharmaceutical Research, 2001, 18: 83-89. Link
to abstract
Merlé Y, Mentré F.
Optimal sampling times for Bayesian estimation of the pharmacokinetic
parameters of nortriptyline during therapeutic drug monitoring, Journal of Pharmacokinetics and Biopharmaceutics, 1999, 27: 85-101. Link to abstract
Tod M, Mentré F, Merlé
Y, Mallet A. Robust optimal design for the estimation of
hyperparameters in population pharmacokinetics, Journal of Pharmacokinetics and Biopharmaceutics, 1998, 26: 689-716. Link to abstract
Mentré F, Mallet A, Baccar D. Optimal design in random-effects regression models, Biometrika, 1997, 84: 429-442. Link to abstract
Merlé Y, Mentré F.
Stochastic optimization algorithms of a Bayesian design criterion for
Bayesian parameter estimation in nonlinear regression models. Application in pharmacokinetics, Mathematical Biosciences, 1997, 144: 45-70. Link to abstract
Mentré F, Burtin P,
Merlé Y, van Bree J, Mallet A, Steimer JL. Sparse-sampling
optimal design in pharmacokinetics and toxicokinetics, Drug Information Journal, 1995, 19: 997-1019.
Merlé Y, Mentré F.
Bayesian design criteria: computation, comparison and application to a
pharmacokinetic and pharmacodynamic model, Journal of Pharmacokinetics and Biopharmaceutics, 1995, 23: 101-124. Link to abstract
Merlé Y, Mentré F,
Mallet A, Aurengo A. Designing an optimal experiment for Bayesian
estimation: application to the kinetic of iodine thyroid uptake, Statistics in Medicine, 1994, 13: 185-196. Link to abstract
Nguyen T.T, Bazzoli C, Mentré F. Design evaluation and optimization in crossover pharmacokinetic studies analyzed by nonlinear mixed effects models. Application to bioequivalence or interaction trials. American Conference in Pharmacometrics, Mashantucket, United-States, October 4-7 2009 (poster, abstract). Link to abstract and PDF of poster
Bazzoli C, Retout S, Mentré F. Prediction of power of test of discrete covariates in population analyses and influence of design: application to gender effect in joint pharmacokinetic models of nucleoside analogs and their active metabolites. American Conference in Pharmacometrics, Mashantucket, United-States, October 4-7 2009 (poster, abstract). Link to abstract and PDF of poster
Bazzoli C, Retout S, Mentré F. Prediction of power of test of discrete covariates in population analyses and influence of design: application to gender effect in joint pharmacokinetic models of nucleoside analogs and their active metabolites. 18th Meeting of Population Approach Group in Europe, St. Petersburg, Russia, June 23-26 2009 (poster, abstract 1627). Link to abstract and PDF of poster
Mentré F, Lavielle M. Stochastic EM algorithms in population pharmacokinetic-pharmacodynamic analyses. American Conference in Pharmacometrics, Tucson, United-States, March 9-12 2008 (oral presentation). Link to abstract and Link to PDF of slides
Bazzoli C, Retout S, Mentré F. An extension of PFIM for optimal population design in multiple response nonlinear mixed effects models: PFIM 3.0. American Conference in Pharmacometrics, Tucson, United-States, June March 9-12 2008 (poster, abstract 79). Link to abstract and PDF of poster
Bazzoli C, Retout S, Rey E, Benech H, Tréluyer J.M, Salmon D, Duval X, Mentré F and the COPHAR2- ANRS 111 study group. 17th Meeting of Population Approach Group in Europe, Marseille, France, June 18-20 2008 (poster, abstract 1373). Link to abstract
Retout S, Comets E, Mentré F, Design optimisation in nonlinear mixed effects models using cost functions: application to a joint model of infliximab and methotrexate pharmacokinetics. 17th Meeting of Population Approach Group in Europe, Marseille, France, June 18-20 2008 (oral presentation, abstract 1344). Link to abstract
Mentré F, Duffull S, Gueorguieva I, Hooker A, Leonov S,
Ogungbenro K, Retout S. Software for optimal design in population pharmacokinetics and pharmacodynamics: a comparison.16th Meeting of the Population Approach Group in Europe, Copenhagen,
Denmark, June 14-16 2007 (oral presentation, abstract 1179).
Link to abstract and PDF of slides
Bazzoli C, Retout S, Mentré F. Population design in nonlinear mixed effects multiple responses models:
extension of PFIM and evaluation by simulation with NONMEM and MONOLIX. 16th Meeting of the Population Approach Group in Europe, Copenhagen, Denmark, June 14-16 2007 (poster, abstract 1176).Link to abstract and PDF of poster
Retout S, Bazzoli, Comets E, Le Nagard, Mentré F.
Population designs evaluation and optimisation in R: the PFIM function
and its new features. 16th Meeting of the Population Approach Group in Europe, Copenhagen, Denmark, June 14-16 2007 (poster, abstract 1164). Link to abstract and PDF of poster
Retout S, Comets E, Samson A, Mentré F. Designs in nonlinear mixed effects models: application to HIV viral
load decrease with evaluation, optimisation and determination of the
power of the test of treatment effect. 5th International Symposium on Measurement and Kineytis of in vivo drug effects, Noordwijkerhout, The Netherlands, April 29-29 2006 (poster).
Retout S, Comets E, Samson A, Mentré F. Designs in nonlinear mixed effects models: application to HIV viral
load decrease with evaluation, optimisation and determination of the
power of the test of a treatment effect. 14th Meeting of the Population Approach Group in Europe, Pamplona, Spain, June 16-17 2005 (poster, abstract 775). Link to abstract
Retout S, Comets E, Mentré F. Comparison between Fedorov-Wynn
algorithm and the Simplex algorithm for population designs optimisation
suing a model for the HIV viral load decrease. 13th Meeting of the Population Approach Groupe in Europe, Uppsala, Sweden, June 17-18 2004 (poster, abstract 527). Link to abstract
Mentré F, Retout S. Optimal designs in non-linear mixed effects
models with application in pharmacokinetics and pharmacodynamics. 23rd Annual Conference of the International Society for Clinical Biostatistics, Dijon, France, September 9-13 2002 (oral presentation).
Nguyen L, Retout S, Mentré F, Variol P, Puozzo C. Population pharmacokinetics of vinflunine from phase I data and
evaluation of population sampling designs for further clinical
development. 11th Meeting of the Population Approach Group in Europe, Paris, France, June 6-7 2002 (poster, abstract 334).
Retout S, Mentré F. Optimisation of individual and population pharmacokinetic designs using Splus. 11th Meeting of the Population Approach Group in Europe, Paris, France, June 6-7 2002 (oral presentation, abstract 342).
Retout S, Mentré F. Optimal designs in non linear mixed effects models: application in population pharmacokinetics. 22th Annual Conference of the International Society for Clinical Biostatistics, Stockholm, Sweden, August 19-23 2001 (poster).
Retout S, Mentré F. Optimal designs in non linear mixed effects models: application to pharmacokinetics. 6th Workshop on Model-Oreinted Design and Analysis, Puchberg, Austria, June 25-29 2001 (oral presentation).
Retout S, Mentré F. Further developments of the Fisher
information matrix for the evaluation of population pharmacokinetic
designs. 10th Meeting of the Population Approach Group in Europe, Basel, Switzerland, June 7-8 2001 (poster, abstract 195).
Retout S, Mentré F, Bruno R. Optimal population designs for enoxaparin pharmacokinetics: evaluation by simulation. 9th Meeting of the Population Approach Group in Europe, Salamanca, Spain, June 15-16 2000 (oral presentation, abstract 86).
Duffull S, Mentré F, Aarons L.Optimal design of a population pharmacodynamic experiment. 9th Meeting of the Population Approach Group in Europe, Salamanca, Spain, June 15-16 2000 (oral presentation, abstract 81).
Duffull S, Mentré F, Aarons L. Optimal design of a population pharmacodynamic experiment for ivabradine. PK UK 99, Oxford, Great Britain, November 10-12 1999 (oral presentation).
Mentré F, Mallet A. Optimal design in nonlinear regression
random effects models with application in population pharmacokinetics. Advances in Model-Oriented Data Analysis and Experimental Design, Marseille, France, June 22-26 1998 (oral presentation).
Mentré F, Mallet A. Optimal design in nonlinear regression
random effects models. Application in population pharmacokinetics. Second Joint Meeting of the Society for Clinical Trials and the International Society for Clinical Biostartistics, Boston, United States, July 7-10 1997 (oral presentation).
Tod M, Merlé M, Mentré F, Mallet A. Robust optimal design in population pharmacokinetics : a new approach. COST B1 Conference : Measuring and managing variability in response, concentration and dose, Geneva, Switzerland, February 12-14 1997 (poster).
Merlé M, Mentré F. A stochastic approximation algorithm to optimize a Bayesian design criterion : Application in
the context of therapeutic drug monitoring to the parameter estimation of a pharmacokinetic model. COST B1 Conference : Measuring and managing variability in response, concentration and dose, Geneva, Switzerland, February 12-14 1997 (poster).
Merlé Y, Mentré F. Performance assessment of three
stochastic optimization algorithms of a Bayesian design criterion for
Bayesian parameter estimation in nonlinear regression models.The XVIIIth International Biometric Conference, Amsterdam, Netherlands, July 1-5 1996 (oral presentation).
Merlé Y, Mentré F. Comparison of Bayesian optimal designs
with respect to variations of the population characteristics for a
pharmacokinetic and a pharmacodynamic model. 15th meeting of the International Society for Clinical Biostatistics, Basel, Switzerland, July 25-29 1994 (oral presentation).
Merlé Y, Mentré F. Comparison of Bayesian optimal designs
with respect to variations of the population characteristics for a
pharmacokinetic and a pharmacodynamic model. Second Meeting of the Population Approach Group in Europe, Greenford, Great Britain, June 13-14, 1994 (oral presentation, abstract 871).
Merlé Y, Mentré F, Mallet A, Aurengo A. Optimal
experimental design for Bayesian Estimation. Application to the
kinetics of Iodine thyroid uptake. 13th International Meeting on Clinical Biostatistics, Copenhagen, Denmark, August 17-21 1992 (oral presentation).
Mallet A, Mentré F. An approach to the design of experiments
for estimating the distribution of parameters in random models. 12th IMACS World Congress, Paris, France, July 18-22 1988 (oral presentation).