Published papers
 

  1. Dumont C, Chenel M, Mentré F.
    Influence of covariance between random effects in design for nonlinear mixed effect models with an illustration in paediatric pharmacokinetics.
    Journal of Biopharmaceutical Statistics, 2014, 24:3, 471-492.
    Link to full text

  2. Nyberg J, Bazzoli C, Ogungbenro K, Aliev A, Leonov S, Duffull S, Hooker AC, Mentré F.
    Methods and software tools for design evaluation for population pharmacokinetics-pharmacodynamics studies. British Journal of Clinical Pharmacology, 2014, in press.
    Link to full text

  3. Combes FP, Retout S, Frey N, Mentré F.
    Power of the likelihood ratio test and of the correlation test using empirical Bayes estimates for various shrinkages in population pharmacokinetics.
    CPT: Pharmacometrics & Systems Pharmacology, 2014, 3: e109.
    Link to full text

  4. Mentré F, Chenel M, Comets E, Grevel J, Hooker A, Karlsson MO, Lavielle M, Gueorguieva I.
    Current use and developments needed for optimal design in pharmacometrics: a study performed amongst DDMoRe's European Federation of Pharmaceutical Industries and Associations (EFPIA) members.
    CPT: Pharmacometrics & Systems Pharmacology, 2013, 2:e46..
    Link to full text

  5. Dumont C, Mentré F, Gaynor C, Brendel K, Gesson C, Chenel M.
    Optimal sampling times for a drug and its metabolite using SIMCYP© simulations as prior information.
    Clinical Pharmacokinetics, 2013, 52:43-57.
    Link to full text

  6. Combes FP, Retout S, Frey N, Mentré F.
    Prediction of shrinkage of individual parameters using the Bayesian information matrix in non-linear mixed effect models with evaluation in pharmacokinetics.
    Pharmaceutical Research, 2013, 30:2355-2367.
    Link to full text

  7. Nguyen TT, Bazzoli C, Mentré F.
    Design evaluation and optimisation in crossover pharmacokinetic studies analysed by nonlinear mixed effects models.
    Statistics in Medicine, 2012, 31: 1043-1058.
    Link to full text

  8. Guedj J, Bazzoli C, Neuman A.U, Mentré F.
    Design evaluation and optimization for models of hepatitis C viral dynamics.
    Statistics in Medicine, 2011, 30:1045-1056.
    Link to abstract

  9. Bazzoli C, Retout S, Mentré F.
    Design evaluation and optimisation in multiple response nonlinear mixed effect models: PFIM 3.0
    Computer Methods and Programs in Biomedicine, 2010, 98: 55-65.
    Link to full text

  10. Retout, S., Comets, E., Bazzoli, C. et Mentré, F. Design
    Optimisation in nonlinear mixed effects models using cost functions:application to a joint model of infliximab and methotrexate pharmacokinetics
    Communication in Statistics: Theory and Methods, 2009, 38 : 3351–3368.
    Link to full text

  11. Bazzoli C, Retout S, Mentré F.
    Fisher information matrix for nonlinear mixed effects multiple response models: evaluation of the appropriateness of the first order linearization using a pharmacokinetic/pharmacodynamic model
    Statistics in Medicine, 2009, 28 : 1940-1956.
    Link to full text

  12. Retout S, Comets E, Samson A, Mentré F.
    Design in nonlinear mixed effects models: optimization using the Fedorov-Wynn algorithm and power of theWald test for binary covariates
    Statistics in Medicine, 2007, 26 : 5162-79.
    Link to abstract

  13. Retout S, Mentré F.
    Further developments of the Fisher information matrix in nonlinear mixed-effects models with  evaluation in population pharmacokinetics
    Journal of Biopharmaceutical Statistics, 2003, 13: 209-227.
    Link to abstract

  14. Retout S, Mentré F.
    Optimisation of individual and population designs using Splus
    Journal of Pharmacokinetic and Pharmacodynamics, 2003, 30: 417-443.
    Link to abstract

  15. Duffull S, Retout S, Mentré F.
    The use of simulated annealing for finding optimal population designs,
    Computer Methods and Programs in Biomedicine, 2002, 69: 25-35.
    Link to abstract

  16. Retout S, Mentré F, Bruno R.
    Fisher information matrix for nonlinear mixed-effects models: evaluation and application for optimal design of enoxaparin population pharmacokinetics
    Statistics in  Medicine, 2002, 21: 2623-2639.
    Link to abstract

  17. Retout S, Duffull S, Mentré F.
    Development and implementation of the population Fisher information matrix for evaluation of population pharmacokinetic designs
    Computer Methods and Programs in Biomedicine, 2001, 65: 141-151.
    Link to abstract

  18. Mentré F, Dubruc C, Thénot JP.
    Population pharmacokinetic analysis of mizolastine solution in children with optimisation of the experimental design
    Journal of Pharmacokinetics and Pharmacodynamics, 2001, 28: 299-319.
    Link to abstract

  19. Duffull S, Mentré F, Aarons L.
    Optimal design of population pharmacodynamic experiment for ivabradine
    Pharmaceutical Research, 2001, 18: 83-89.
    Link to abstract

  20. Merlé Y, Mentré F.
    Optimal sampling times for Bayesian estimation of the pharmacokinetic parameters of nortriptyline during therapeutic drug monitoring
    Journal of Pharmacokinetics and Biopharmaceutics, 1999, 27: 85-101.
    Link to abstract

  21. Tod M, Mentré F, Merlé Y, Mallet A.
    Robust optimal design for the estimation of hyperparameters in population pharmacokinetics
    Journal of Pharmacokinetics and Biopharmaceutics, 1998, 26: 689-716.
    Link to abstract

  22. Mentré F, Mallet A, Baccar D.
    Optimal design in random-effects regression models
    Biometrika, 1997, 84: 429-442.
    Link to abstract

  23. Merlé Y, Mentré F.
    Stochastic optimization algorithms of a Bayesian design criterion for Bayesian parameter estimation in nonlinear regression models. Application in pharmacokinetics
    Mathematical Biosciences, 1997, 144: 45-70.
    Link to abstract

  24. Mentré F, Burtin P, Merlé Y, van Bree J, Mallet A, Steimer JL.
    Sparse-sampling optimal design in pharmacokinetics and toxicokinetics
    Drug Information Journal, 1995, 19: 997-1019.

  25. Merlé Y, Mentré F.
    Bayesian design criteria: computation, comparison and application to a pharmacokinetic and pharmacodynamic model
    Journal of Pharmacokinetics and Biopharmaceutics, 1995, 23: 101-124.
    Link to abstract

  26. Merlé Y, Mentré F, Mallet A, Aurengo A.
    Designing an optimal experiment for Bayesian estimation: application to the kinetic of iodine thyroid uptake
    Statistics in  Medicine, 1994, 13: 185-196.
    Link to abstract

Invited international conferences
  1. Mentré F.
    Design considerations in population PKPD.
    Workshop Applications of Modeling and Simulation in Drug Development, Hasselt, Belgium, December 12-13 2013.

  2. Mentré F, Dumont C, Chenel M.
    Two-stage optimal designs in nonlinear mixed effect models: application to pharmacokinetics in children.
    Seventh International Workshop on Simulation, Rimini, Italy, May 21-25, 2013.

  3. Combes F, Retout S, Frey N, Mentré F
    Influence of study design and associated shrinkage on power of the tests used for covariate detection in population pharmacokinetics.
    Workshop on Population Optimal Design of Experiments, London, UK, June 15 2013.
    pdf of slides

  4. Dumont C, Chenel M, Mentré F.
    Two-stage optimal designs in nonlinear mixed effect models: application to pharmacokinetics in children.
    The International Conference on Trends and Perspectives in Linear Statistical Inference and The 21st International Workshop on Matrices and Statistics, Bedlewo, Poland, July 16-20 2012.

  5. Mentré F.
    Survey on the current use of optimal design approaches and the needed developments in adaptive optimal design for model based analysis performed in the EFPIA members of the DDMoRe project.
    Workshop on Population Optimal Design of Experiments, Paris, France, March 22-23 2012.
    PDF of slides

  6. Combes F, Retout S, Frey N, Mentré F.
    Prediction of shrinkage of individual parameters using the Bayesian information matrix in nonlinear mixed-effect models with application in pharmacokinetics.
    Workshop on Population Optimal Design of Experiments, Paris, France, March 22-23 2012.
    PDF of slides

  7. Mentré F, Bazzoli C.
    Optimal designs for pharmacokinetic and viral dynamic nonlinear mixed effect models in HIV treatment.
    2nd International BIO-SI Workshop on Biostatistics, Rennes, France, October 6-7 2011.

  8. Mentré F, Bazzoli C.
    Optimal designs for pharmacokinetic and viral dynamic nonlinear mixed effect models in HIV treatment.
    Workshop on Optimum Design for Mixed Effects Non-linear and Generalised Linear Models, Cambridge, UK, August 9-12 2011.
    Link to abstract and PDF of slides

  9. Mentré F, Nyberg J, Ogungbenro K, Leonov S, Aliev A, Duffull S, Bazzoli C, Hooker AC.
    Comparison of results of the different software for design evaluation in population pharmacokinetics and pharmacodynamics.
    Workshop on Optimum Design for Mixed Effects Non-linear and Generalised Linear Models, Cambridge, UK, August 9-12 2011.
    PDF of slides

  10. Nguyen TT, Mentré F.
    Using Gaussian Quadrature method for computing Fisher information matrix in dose-response trials analyzed by nonlinear mixed effects models.
    International Conference on Design of Experiments, Memphis, US, May 10-13 2011.
    Link to abstract

  11. Mentré F, Nguyen TT, Guedj J, Bazzoli C.
    Optimal design for nonlinear mixed effect modeling of dose-exposure-response.
    The Second International Symposium on Biopharmaceutical Statistics, Berlin, Germany, March 1-3 2011.

  12. Mentré F, N’Guyen TT, Dubois A, Bazzoli C.
    Optimal design in bioequivalence studies analyzed with nonlinear mixed effect models. Joint Statistical Meeting, Vancouver, Canada, July 31 – August 5 2010.
    Link to abstract

  13. Guedj J, Bazzoli C, Neumann A, Mentré F.
    Design evaluation and optimization for models of Hepatatis C viral dynamics.  Workshop on Population Optimal Design of Experiments,Berlin, Germany, June 11-12 2010.
    Link to abstract

  14. N’Guyen TT, Bazzoli C, Mentré F.
    Design evaluation and optimisation in crossover pharmacokinetic studies analyzed by nonlinear mixed effects models.
    Workshop on Population Optimal Design of Experiments,Berlin, Germany, June 11-12 2010.
    Link to abstract and PDF of slides

  15. Mentré F, Bazzoli C.
    Comparison of software tools for population optimal designs.
    Workshop on Population Optimal Design of Experiments, St Petersburg, Russia, June 27 2009.

  16. Bazzoli C, Retout S, Comets E, Mentré F.
    Optimal design with cost functions for the pharmacokinetics of AZT and AZT-TP.
    Workshop on Population Optimal Design of Experiments, Paris, France, June 23 2008.PDF of slides

  17. Retout S, Mentré F
    Sparse sampling design in population pharmacokinetics/ pharmacodynamics studies.
    EMEA Workshop on Modelling in Paediatric Medicines,  London, United-Kingdom, April 14-15 2008.

  18. Bazzoli C, Retout S, Mentré F.
    Population design in nonlinear mixed effects multiple responses models: extension of PFIM and evaluation by simulation with NONMEM and MONOLIX.
    Workshop on Population Optimal Design of Experiments, Sandwich, United Kingdom, May 4 2007.
    Link to abstract and PDF of slides

  19. Retout S, Bazzoli C, Comets E, Le Nagard H,  Mentré F.
    Population designs evaluation and optimisation in R: the PFIM function and its new features.
    Workshop on Population Optimal Design of Experiments, Sandwich, United Kingdom, May 4 2007. Link to abstract and PDF of slides

  20. Mentré F. Optimal design in population pharmacokinetic/pharmacodynamic models.
    Lewis B. Sheiner Memorial Symposium, Washington, USA, December 4-5 2006.
    Link to PDF of slides 

  21. Retout S, Comets E, Samson A, Mentré F.
    Optimal designs in nonlinear mixed-effects: applications for population pharmacokinetic/phramacodynamic studies.
    Joint Statistical Meeting 2006, Seattle, USA, August 6-10 2006. Link to abstract book

  22. Retout S, Comets E, Samson A, Mentré F.
    Designs in nonlinear mixed-effects: evaluation and optimisation of the power of the Wald test with application to HIV viral load decrease.
    Workshop on Population Optimal Design of Experiments, London,United Kingdom, May 15 2006.
    Link to abstract and PDF of slides

  23. Mentré F, Retout S, Samson A, Comets E.
    Designs in nonlinear mixed-effects for a model of HIV viral load decrease: evalutaion, optimisation and determintaion fo the power of treatment effect.
    International Conference on Design of Experiments: theory and applications, Memphis, USA, May 13-15 2005.

  24. Retout S,  Mentré F.
    Optimisation of individual and population pharmacokinetic designs using S-Plus.
    14th DIA International Workshop on Statistical Methodology in Clinical R&D, Paris, France, April 7-9 2003.

  25. Mentré F, Retout S.
    Optimal designs in population pharmacokinetics/ pharmacodynamics clinical trials.
    5th Meeting of the Population Approach Group in Australia and New Zealand, Sydney, Australia, February 19-21 2003.

  26. Mentré F.
    Optimal designs in population pharmacokinetics/ pharmacodynamics.
    9th Workshop on Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis, Los Angeles, United State, June 22-23 2001.

  27. Mentré F.
    Optimal design in population pharmacokinetics.
    The XIXth International Biometric Conference,  Cap Town, South of Africa, December 14-18 1998.

  28. Mentré F.
    Optimal experimental design in population pharmacokinetics.
    Third Meeting of the Population Approach Group in Europe,  Sandwich, United Kingdom, June 14-15 1996.

  29. Mentré F.
    Optimal experimental design in population analysis: population designs and Bayesian designs.
    5th Annual Drug Information Association European Workshop on Statistical Methodology in Clinical Research and Development, Edimburgh, Great Britain, April 25-27 1994.

  30. Mentré F.
    Optimal design in population analysis including Bayesian aspects.
    First Meeting of the Population Approach Group in Europe,  Paris, France, June 25 1993.

Other international conferences

  1. Nguyen TT, Mentré F.
    Evaluation of the Fisher information matrix using Gaussian quadrature for designing dose-response studies analysed by nonlinear mixed effects models.
    7th International Meeting on Statistical Methods in Biopharmacy, Paris, 16-17 septembre, 2013.

  2. Dumont C, Chenel M, Mentré F.
    Influence of the ratio of the sample sizes between the two stages of an adaptive design: application for a population pharmacokinetic study in children
    22nd Meeting of the Population Approach Group in Europe, Glasgow, Scotland, June 11-14 2013 (poster).
    Link to abstract And pdf of poster

  3. Combes F, Retout S, Frey N, Mentré F.
    Prediction of precision of individual parameter estimates and of shrinkage via the Bayesian Fisher information matrix in non-linear mixed-effects models with application in pharmacokinetics
    21st Meeting of the Population Approach Group in Europe, Venice, Italy, June 5-8 2012 (poster).
    Link to abstract And pdf of poster

  4. Dumont C, Chenel M, Mentré F.
    Optimal two-stage design for a population pharmacokinetic study in children.
    21st Meeting of the Population Approach Group in Europe, Venice, Italy, June 5-8 2012 (poster).
    Link to abstract And pdf of poster

  5. Mentré F.
    Survey on the current use of optimal design approaches and the needed developments in adaptive optimal design for model based analysis performed in the EFPIA members of the DDMoRe project.
    21st Meeting of the Population Approach Group in Europe, Venice, Italy, June 5-8 2012 (oral presentation).
    PDF of slides

  6. Bazzoli C, Nguyen TT, Comets E, Dubois A, Le Nagard H, Mentré F.
    New features for population design evaluation and optimisation with R functions: PFIM Interface 3.1 and PFIM 3.2.
    20th Meeting of Population Approach Group in Europe, Athens, Greece, June 7-10 2011 (poster).
    Link to abstract and PDF of poster

  7. Dubois A, Nguyen TT, Lowe P, Mentré F.
    Evaluation of designs for biosimilarity crossover trials analysed by nonlinear mixed effects models.
    20th Meeting of Population Approach Group in Europe, Athens, Greece, June 7-10 2011 (poster).
    Link to abstract

  8. Dumont C, Chenel M, Mentré F.
    Design evaluation in nonlinear mixed effect models : influence of covariance between random effects.
    20th Meeting of Population Approach Group in Europe, Athens, Greece, June 7-10 2011 (poster).
    Link to abstract and PDF of poster

  9. Mentré F, Nyberg J, Ogungbenro K, Leonov S, Aliev A, Duffull S, Bazzoli C, Hooker AC.
    Comparison of results of the different software for design evaluation in population pharmacokinetics and pharmacodynamics.
    20th Meeting of Population Approach Group in Europe, Athens, Greece, June 7-10 2011 (poster).
    Link to abstract and PDF of poster

  10. Nguyen TT, Mentré F.
    Using Gaussian quadrature for computing Fisher information matrix in dose-response trials analyzed by nonlinear mixed effects models.
    20th Meeting of Population Approach Group in Europe, Athens, Greece, June 7-10 2011 (poster).
    Link to abstract

  11. Nguyen TT, Bazzoli C, Mentré F.
    Designing a dose-response study analysed by nonlinear mixed effects models.
    20th Meeting of Population Approach Group in Europe, Athens, Greece, June 7-10 2011 (poster).
    Link to abstract and PDF of poster

  12. N’Guyen TT, Bazzoli C, Dubois A, Mentré F. Design
    Evaluation and optimisation in crossover bioequivalence trials analyzed with nonlinear mixed effects models.
    XXXIVth International Society for Clinical Biostatistics, Montpellier, France, August 29- September 2 2010, (oral presentation). PDF of slides

  13. Bazzoli C, Retout S, Mentré F.
    Design evaluation and optimisation in multi-response nonlinear mixed effect models with cost functions: application to the pharmacokinetics of zidovudine and its active metabolite.
    19th Meeting of the Population Approach Group in Europe, Berlin, Germany, June 9-11 2010 (oral presentation). Link to abstract and PDF of slides

  14. Guedj J, Bazzoli C, Neumann A, Mentré F.
    Design evaluation and optimization for models of Hepatitis C viral dynamics.  19th Meeting of the Population Approach Group in Europe, Berlin, Germany, June 9-11 2010 (poster).
    Link to abstract and PDF of poster

  15. Bazzoli C, Dubois A, N’Guyen TT, Mentré F.
    New features for population design evaluation and optimisation using PFIM3.2: illustration on warfarin pharmacokinetics – pharmacodynamics.
    19th Meeting of the Population Approach Group in Europe, Berlin, Germany, June 9-11 2010 (poster).
    Link to abstract and PDF of poster

  16. N’Guyen TT, Bazzoli C, Mentré F.
    Design evaluation and optimisation in crossover pharmacokinetic studies analyzed by nonlinear mixed effects models.
    19th Meeting of the Population Approach Group in Europe, Berlin, Germany, June 9-11 2010 (poster).
    Link to abstract and PDF of poster.

  17. Bazzoli C, NGuyen TT, Dubois A, Mentré F.
    New features for population design evaluation and optimisation using PFIM3.2: illustration on warfarin pharmacokinetics - pharmacodynamics.
    6th International Symposium on Measurement and Kinetics of In Vivo drug effects, Noordwijkerhout, Netherland, April 21-24 2010 (poster). 

  18. Nguyen T.T, Bazzoli C, Mentré F.
    Design evaluation and optimization in crossover pharmacokinetic studies analyzed by nonlinear mixed effects models. Application to bioequivalence or interaction trials.
    American Conference in Pharmacometrics, Mashantucket, United-States, October 4-7 2009 (poster, abstract). Link to abstract and PDF of poster

  19. Bazzoli C, Retout S, Mentré F.
    Prediction of power of test of discrete covariates in population analyses and influence of design: application to gender effect in joint pharmacokinetic models of nucleoside analogs and their active metabolites. American Conference in Pharmacometrics, Mashantucket, United-States, October 4-7 2009 (poster, abstract).
    Link to abstract and PDF of poster

  20. Bazzoli C, Retout S, Mentré F.
    Prediction of power of test of discrete covariates in population analyses and influence of design: application to gender effect in joint pharmacokinetic models of nucleoside analogs and their active metabolites.
    18th Meeting of Population Approach Group in Europe, St. Petersburg, Russia, June 23-26 2009 (poster, abstract 1627).
    Link to abstract and PDF of poster

  21. Mentré F, Lavielle M.
    Stochastic EM algorithms in population pharmacokinetic-pharmacodynamic analyses.
    American Conference in Pharmacometrics, Tucson, United-States, March 9-12 2008 (oral presentation).
    Link to abstract and Link to PDF of slides

  22. Bazzoli C, Retout S, Mentré F.
    An extension of PFIM for optimal population design in multiple response nonlinear mixed effects models: PFIM 3.0.
    American Conference in Pharmacometrics, Tucson, United-States, June March 9-12 2008 (poster, abstract 79).
    Link to abstract and PDF of poster

  23. Bazzoli C, Retout S, Rey E, Benech H, Tréluyer J.M, Salmon D, Duval X, Mentré F and the COPHAR2- ANRS 111 study group.
    17th Meeting of Population Approach Group in Europe, Marseille, France, June 18-20 2008 (poster, abstract 1373).
    Link to abstract

  24. Retout S, Comets E, Mentré F,
    Design optimisation in nonlinear mixed effects models using cost functions: application to a joint model of infliximab and methotrexate pharmacokinetics.
    17th Meeting of Population Approach Group in Europe, Marseille, France, June 18-20 2008 (oral presentation, abstract 1344).
    Link to abstract

  25. Mentré F, Duffull S, Gueorguieva I, Hooker A, Leonov S, Ogungbenro K, Retout S.
    Software for optimal design in population pharmacokinetics and pharmacodynamics: a comparison.16th Meeting of the Population Approach Group in Europe, Copenhagen, Denmark, June 14-16 2007 (oral presentation, abstract 1179).
    Link to abstract and PDF of slides

  26. Bazzoli C, Retout S, Mentré F.
    Population design in nonlinear mixed effects multiple responses models: extension of PFIM and evaluation by simulation with NONMEM and MONOLIX.
    16th Meeting of the Population Approach Group in Europe, Copenhagen, Denmark, June 14-16 2007 (poster, abstract 1176).
    Link to abstract and PDF of poster 

  27. Retout S, Bazzoli, Comets E, Le Nagard,  Mentré F.
    Population designs evaluation and optimisation in R: the PFIM function and its new features.
    16th Meeting of the Population Approach Group in Europe, Copenhagen, Denmark, June 14-16 2007 (poster, abstract 1164).
    Link to abstract and PDF of poster

  28. Retout S, Comets E, Samson A, Mentré F.
    Designs in nonlinear mixed effects models: application to HIV viral load decrease with evaluation, optimisation and determination of the power of the test of treatment effect.
    5th International Symposium on Measurement and Kineytis of in vivo drug effects, Noordwijkerhout, The Netherlands, April 29-29 2006 (poster).

  29. Retout S, Comets E, Samson A, Mentré F.
    Designs in nonlinear mixed effects models: application to HIV viral load decrease with evaluation, optimisation and determination of the power of the test of a treatment effect.
    14th Meeting of the Population Approach Group in Europe, Pamplona, Spain, June 16-17 2005 (poster, abstract 775).
    Link to abstract

  30. Retout S, Comets E, Mentré F.
    Comparison between Fedorov-Wynn algorithm and the Simplex algorithm for population designs optimisation suing a model for the HIV viral load decrease.
    13th Meeting of the Population Approach Groupe in Europe, Uppsala, Sweden, June 17-18 2004 (poster, abstract 527).
    Link to abstract

  31. Mentré F, Retout S.
    Optimal designs in non-linear mixed effects models with application in pharmacokinetics and pharmacodynamics.
    23rd Annual Conference of the International Society for Clinical Biostatistics, Dijon, France, September 9-13 2002 (oral presentation).

  32. Nguyen L, Retout S, Mentré F, Variol P, Puozzo C.
    Population pharmacokinetics of vinflunine from phase I data and evaluation of population sampling designs for further clinical development.
    11th Meeting of the Population Approach Group in Europe, Paris, France, June 6-7 2002 (poster, abstract 334).

  33. Retout S, Mentré F.
    Optimisation of individual and population pharmacokinetic designs using Splus.
    11th Meeting of the Population Approach Group in Europe, Paris, France, June 6-7 2002 (oral presentation, abstract 342).

  34. Retout S, Mentré F.
    Optimal designs in non linear mixed effects models: application in population pharmacokinetics.
    22th Annual Conference of the International Society for Clinical Biostatistics, Stockholm, Sweden, August 19-23 2001 (poster).

  35. Retout S, Mentré F.
    Optimal designs in non linear mixed effects models: application to pharmacokinetics.
    6th Workshop on Model-Oreinted Design and Analysis,  Puchberg, Austria, June 25-29 2001 (oral presentation).

  36. Retout S, Mentré F.
    Further developments of the Fisher information matrix for the evaluation of population pharmacokinetic designs.
    10th Meeting of the Population Approach Group in Europe, Basel, Switzerland, June 7-8 2001 (poster, abstract 195).

  37. Retout S, Mentré F, Bruno R.
    Optimal population designs for enoxaparin pharmacokinetics: evaluation by simulation.
    9th Meeting of the Population Approach Group in Europe,  Salamanca, Spain, June 15-16 2000 (oral presentation, abstract 86).

  38. Duffull S, Mentré F, Aarons L.
    Optimal design of a population pharmacodynamic experiment.
    9th Meeting of the Population Approach Group in Europe, Salamanca, Spain, June 15-16 2000 (oral presentation, abstract 81).

  39. Duffull S, Mentré F, Aarons L.
    Optimal design of a population pharmacodynamic experiment for ivabradine.
    PK UK 99, Oxford, Great Britain, November 10-12 1999 (oral presentation).

  40. Mentré F, Mallet A.
    Optimal design in nonlinear regression random effects models with application in population pharmacokinetics.
    Advances in Model-Oriented Data Analysis and Experimental Design, Marseille, France, June 22-26 1998 (oral presentation).

  41. Mentré F, Mallet A. Optimal design in nonlinear regression random effects models. Application in population pharmacokinetics.
    Second Joint Meeting of the Society for Clinical Trials and the International Society for Clinical Biostartistics, Boston, United States, July 7-10 1997 (oral presentation).

  42. Tod M, Merlé M, Mentré F, Mallet A.
    Robust optimal design in population pharmacokinetics : a new approach. COST B1 Conference : Measuring and managing variability in response, concentration and dose,  Geneva, Switzerland, February 12-14 1997 (poster).

  43. Merlé M, Mentré F.
    A stochastic approximation algorithm to optimize a Bayesian design criterion : Application in the context of therapeutic drug monitoring to the parameter estimation of a pharmacokinetic model.
    COST B1 Conference : Measuring and managing variability in response, concentration and dose, Geneva, Switzerland, February 12-14 1997 (poster).

  44. Merlé Y, Mentré F.
    Performance assessment of three stochastic optimization algorithms of a Bayesian design criterion for Bayesian parameter estimation in nonlinear regression models.
    The XVIIIth International Biometric Conference, Amsterdam, Netherlands, July 1-5 1996 (oral presentation).

  45. Merlé Y, Mentré F.
    Comparison of Bayesian optimal designs with respect to variations of the population characteristics for a pharmacokinetic and a pharmacodynamic model.
    15th meeting of the International Society for Clinical Biostatistics, Basel, Switzerland, July 25-29 1994 (oral presentation).

  46. Merlé Y, Mentré F.
    Comparison of Bayesian optimal designs with respect to variations of the population characteristics for a pharmacokinetic and a pharmacodynamic model.
    Second Meeting of the Population Approach Group in Europe, Greenford, Great Britain, June 13-14, 1994 (oral presentation, abstract 871).

  47. Merlé Y, Mentré F, Mallet A, Aurengo A.
    Optimal experimental design for Bayesian Estimation. Application to the kinetics of Iodine thyroid uptake.
    13th International Meeting on Clinical Biostatistics, Copenhagen, Denmark, August 17-21 1992 (oral presentation).

  48. Mallet A, Mentré F.
    An approach to the design of experiments for estimating the distribution of parameters in random models.
    12th IMACS World Congress, Paris, France, July 18-22 1988 (oral presentation).

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